Ivermectin and albendazole alone and in combination for the treatment of lymphatic filariasis in Ghana: follow-up after re-treatment with the combination.
Identifieur interne : 012C71 ( Main/Exploration ); précédent : 012C70; suivant : 012C72Ivermectin and albendazole alone and in combination for the treatment of lymphatic filariasis in Ghana: follow-up after re-treatment with the combination.
Auteurs : Samuel K. Dunyo [Ghana] ; Paul E. SimonsenSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Albendazole (administration et posologie), Animaux, Antihelminthiques (administration et posologie), Association de médicaments, Enfant, Femelle, Filaricides (administration et posologie), Filariose lymphatique (traitement médicamenteux), Ghana, Humains, Ivermectine (administration et posologie), Mâle, Récidive, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Wuchereria bancrofti, Études de suivi.
- MESH :
- administration et posologie : Albendazole, Antihelminthiques, Filaricides, Ivermectine.
- traitement médicamenteux : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association de médicaments, Enfant, Femelle, Ghana, Humains, Mâle, Récidive, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Wuchereria bancrofti, Études de suivi.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Albendazole (administration & dosage), Animals, Anthelmintics (administration & dosage), Child, Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Female, Filaricides (administration & dosage), Follow-Up Studies, Ghana, Humans, Ivermectin (administration & dosage), Male, Middle Aged, Recurrence, Treatment Outcome, Wuchereria bancrofti.
- MESH :
- chemical , administration & dosage : Albendazole, Anthelmintics, Filaricides, Ivermectin.
- geographic : Ghana.
- drug therapy : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Recurrence, Treatment Outcome, Wuchereria bancrofti.
Abstract
The efficacy of re-treatment with the combination of ivermectin (150-200 micrograms/kg bodyweight) and albendazole (400 mg) on Wuchereria bancrofti microfilaraemia was assessed in 1997-99 in 4 groups of individuals from coastal Ghana, which 1 year previously had received a primary treatment with placebo (n = 38), albendazole (n = 39), ivermectin (n = 34) or combination of albendazole and ivermectin (n = 42), respectively. One year after the re-treatment, an overall mean reduction in microfilarial intensity of 76.2% in relation to the intensity before re-treatment was observed, with no statistical significant difference between the 4 groups. The groups given primary treatment with placebo or the drug combination showed re-treatment reductions which were lower (72.5% and 69.8%, respectively) but not statistically significantly different from the reduction observed 1 year after the primary treatment with the combination (86.7%). The efficacy of the combination treatment thus appeared to be largely independent of the type of primary treatment given and multiplicative when used repeatedly.
PubMed: 12055812
Affiliations:
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One year after the re-treatment, an overall mean reduction in microfilarial intensity of 76.2% in relation to the intensity before re-treatment was observed, with no statistical significant difference between the 4 groups. The groups given primary treatment with placebo or the drug combination showed re-treatment reductions which were lower (72.5% and 69.8%, respectively) but not statistically significantly different from the reduction observed 1 year after the primary treatment with the combination (86.7%). The efficacy of the combination treatment thus appeared to be largely independent of the type of primary treatment given and multiplicative when used repeatedly.</div></front></TEI><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><noCountry><name sortKey="Simonsen, Paul E" sort="Simonsen, Paul E" uniqKey="Simonsen P" first="Paul E" last="Simonsen">Paul E. Simonsen</name></noCountry><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Dunyo, Samuel K" sort="Dunyo, Samuel K" uniqKey="Dunyo S" first="Samuel K" last="Dunyo">Samuel K. Dunyo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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